Description
What is Apalutamide?
Apalutamide is a medication that is used for the treatment of prostate cancer. Doctors prescribe it for –
– Non-metastatic castration-resistant prostate cancer (nmCRPC)
– Metastatic castration-sensitive prostate cancer (mCSPC)
Being an androgen receptor (AR) inhibitor, Apalutamide checks the growth of the androgen (male hormones such as testosterone) receptor pathway which helps prostate cancer cells multiply and survive.
How does Apalutamide work?
To understand working of this medicine, let’s take a brief look into its mechanism of action-
Androgen Receptor Inhibition
Apalutamide blocks androgen receptors. Thereby, inhibiting the androgen receptor signaling pathway.
Prevention of AR Nuclear Translocation
Apalutamide prevents the androgen-receptor complex from moving into the nucleus and stops it from affecting gene expression.
Inhibition of DNA Binding and Transcription
If the androgen-receptor complex still enters the nucleus, Apalutamide doesn’t let it bind to DNA. Thereby, stopping the growth of genes that help prostate cancer cells survive and reducing tumor growth.
Indian generic Apalutamide manufacturer
BDR Pharmaceutical has launched the first generic Apalutamide with the brand name Apatide in India. It aims at the treatment of both metastatic castration-sensitive prostate cancer and non-metastatic castration-resistant prostate cancer. The product is available across the country in 60 mg strength. It is available in two packs – 60 tabs and 120 tabs.
Apalutamide Brands in India
In India, Apalutamide is manufactured under various brand names. Some of the common brands of Apalutamide available in India include:
Apatide
Launched by BDR Pharmaceuticals, Apatide is the first generic version of Apalutamide in India. It is available in 60 mg strength and is used to treat both metastatic castration-sensitive prostate cancer (mCSPC) and non-metastatic castration-resistant prostate cancer (nmCRPC).
BDR Pharmaceuticals has been instrumental in making generic Apalutamide accessible in India, thereby contributing significantly to the treatment options available for prostate cancer patients in the country.
Apnat by Natco Pharma
Natco Pharma’s brand of Apalutamide is marketed under the name “Apnat.” Apnat is used to treat two types of prostate cancer in adult men: mCSPC and nmCRPC.
The standard dosage is 240 mg per day, which equates to four 60 mg tablets taken once daily. Patients often receive it in conjunction with a gonadotropin-releasing hormone (GnRH) analog or after a bilateral orchiectomy.
Consult a healthcare provider or pharmacist for the most accurate and up-to-date information.
Apalutamide Price in India
– Apatide by BDR Pharmaceuticals for a bottle of 60 tablets costs INR 22,500.
– Apnat by Natco Pharma Ltd. costs INR 28000 for a bottle of 120 tablets.
– Proapaci by Cipla Ltd. costs INR 32740 for a bottle of 120 tablets.
– Erlamide by Sun Pharma Laboratories Ltd costs INR 16381 to INR 32763 for a bottle of 60 tablets.
Please note: The cost of Apalutamide in India varies based on the strength that the doctor has prescribed and the specific brand. The above cost is tentative.
How to Buy Apalutamide Online?
Get a Prescription: Consult your doctor for a prescription.
Choose a trusted supplier: Use reputable supplier.
You can also contact Delightaid Health, we can help you to get high quality generic Apalutamide medicine at the lowest discounted cost.
Please contact us via Email, WhatsApp or simply filling query form in our website bottom section or contact us page.
The customer will have to present a medical prescription (legal) prescribed from a doctor.
What are the Benefits of Apalutamide?
Delays Disease Progression
Clinical trials have shown that Apalutamide significantly delays the progression of prostate cancer in patients with nmCRPC and mCSPC. By inhibiting the androgen receptor pathway, it controls the disease and prolongs the time before metastasis occurs.
Improves Overall Survival
Studies have demonstrated that Apalutamide improves overall survival rates in patients.
Enhances Quality of Life
By controlling cancer progression and delaying metastasis, Apalutamide maintains the quality of life for patients.
Apalutamide comparison with other prostrate cancer medicines
This comparative content highlights the key differences and similarities between Apalutamide, Enzalutamide, and Abiraterone, providing valuable information and treatment options for prostate cancer.
| Comparison Parameters | Apalutamide | Enzalutamide | Abiraterone |
|---|---|---|---|
| Mechanism of Action | An androgen receptor (AR) inhibitor that prevents AR nuclear translocation, DNA binding, and AR-mediated transcription. | An AR inhibitor that works by inhibiting AR nuclear translocation, DNA binding, and interaction with co-activators. | A CYP17 inhibitor that reduces androgen production by inhibiting CYP17 enzyme activity in the testes, adrenal glands, and prostate tumor tissue. |
| Clinical Considerations | Suitable for patients with nmCRPC and mCSPC, especially those who need therapy with a relatively lower risk of drug interactions. | Versatile option for various stages of prostate cancer but requires careful monitoring for potential drug interactions and neurological side effects. | Effective for mCRPC and mCSPC, but requires additional steroid management and monitoring for cardiovascular and hepatic side effects. |
| Indications | Approved for non-metastatic castration-resistant prostate cancer (nmCRPC) and metastatic castration-sensitive prostate cancer (mCSPC) | Approved for nmCRPC, metastatic castration-resistant prostate cancer (mCRPC), and mCSPC | Approved for mCRPC and mCSPC |
| Efficacy | Clinical trials have shown a significant delay in metastasis and improved overall survival in nmCRPC and mCSPC patients | Proven to delay progression and improve survival in nmCRPC, mCRPC, and mCSPC, with multiple clinical trials supporting its efficacy | Proven to improve overall survival and delay progression in mCRPC and mCSPC, with significant benefits in hormone-sensitive settings |
In Conclusion
Simply put, Apalutamide is a vital medication that fights against advanced prostate cancer. By effectively inhibiting the androgen receptor pathway, it helps delay disease progression, improve survival rates, and enhance the quality of life for patients. Its role in prostate cancer treatment highlights the importance of targeted therapies in managing this challenging disease.
FAQs
What is the life expectancy with Apalutamide?
The Apalutamide life expectancy varies based on several factors – the stage and type of prostate cancer, the patient’s health, and how the cancer responds to treatment.
Is Apalutamide considered chemotherapy?
No, Apalutamide is not considered chemotherapy. Instead, it is classified as a type of hormone therapy, specifically a nonsteroidal antiandrogen.
How successful is Apalutamide?
The success of Apalutamide in the treatment of prostate cancer has been demonstrated in several clinical trials, for patients with nmCRPC and mCSPC.
What is the drug Apalutamide used for?
Apalutamide is a medication primarily used for the treatment of prostate cancer. It is specifically used for nmCRPC and mCSPC.
Can Apalutamide cure prostate cancer?
Apalutamide is not a cure for prostate cancer. However, it effectively helps manage the disease, slow its progression, & improve survival outcomes.
What is the cost of Apalutamide in India?
The cost of Apalutamide in India varies based on the specific brand which ranges around INR 16381 to INR 32763.
What is the cost of prostate treatment in India?
The cost of prostate cancer treatment in India varies widely as per the type of treatment – chemotherapy, radiation therapy, hormone therapy, & surgery.
References –
https://www.hexahealth.com/blog/prostate-cancer-treatment-in-india
NOTE:
This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this product. It does not include all information about the possible uses, directions, side effects, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This is prescription medicine and if you want to buy this medication legally from Delightaid Health, we require a valid prescription from you. Please consult with your doctor before taking this medicine. Only your doctor can decide which medicine is good for you. Please read the disclaimer and prescription-related full details at the bottom of this website.
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