Olaparib Generic Price in India

Description

Olaparib is prescribed to patients with specific types of cancer at targeted stages of their treatment. For example, it is used following surgery in the treatment of high-risk early-stage breast cancer that has been previously treated with chemotherapy, either before or after surgery, as well as for metastatic breast cancer that has been treated with chemotherapy, regardless of whether the cancer has spread.

In the case of certain ovarian cancers, olaparib is employed as a maintenance therapy for patients who have achieved a complete or partial response to platinum-based chemotherapy.

Olaparib Dosage Forms and Strengths

• Tablets: 100 mg and 150 mg.
• Common doses for patients are typically 150 mg twice daily.

Note: Please adhere to your doctor’s recommendations regarding the prescribed dosage.

Generic Olaparib in India

Olaparib Generic is available in India under different manufacturers with their own brand names.

Generic Olaparib options are available in India, with pricing potentially lower than the branded form. As per sources, the yearly cost of generic Olaparib in India is capped at INR 3 lakh, while the original branded version costs about INR 72 lakh in India. This makes the generic version significantly more affordable for patients. Thus, this situation directly affects many of cancer patients in India.

Generic Olaparib in India offers an affordable alternative for cancer patients, making advanced treatment accessible.

With its lower costs compared to branded versions, it significantly improves access to life-saving therapy, providing hope to many who are fighting cancer.

Olaparib Cost in India

It is important to highlight that Olaparib is a high-cost medication, often classified as a specialty drug due to its advanced formulation and targeted therapeutic approach.

Olaparib price varies by region, with prices typically higher in the USA and Europe.

In India, Available through various Indian manufacturers like Glenmark, Natco, Zydus, Dr. Reddy’s, and Cipla. Prices may range depending on the manufacturer and dosage.

Natco Pharma, based in Hyderabad, was the first company in India to introduce a generic version of Olaparib.

Here are some of the easily available Olaparib manufacturers in India with their respective costs:

1. Glenmark (OLPARIB)
   • INR 12497 (150 mg a bottle of 60 tablets)
   • INR 7373.44 (100 mg a bottle of 60 tablets)

2. Natco Pharma (Bracanat)
   • INR 21150 (150 mg, a bottle of 30 capsules)
   • INR 18330 (100 mg, a bottle of 30 tablets)

3. Zydus (Ibyra) 
   • INR 25000 (approx.) (100 mg, a bottle of 30 tablets)

4. Dr Reddy’s (Ribaxa)
   • INR 13573 (150 mg, a bottle of 60 tablets)
   • INR 9400 (100 mg, a bottle of 60 tablets)

5. Cipla (OBParp)
   • INR 2077 (150 mg, 8 tablets in a bottle)
   • INR 1760 (100 mg, a strip of 8 tablets)

6. Intas (OLPAZA) 
   • INR 6011 (150 mg, a bottle of 30 tablets)
   • INR 4072 (100 mg, a bottle of 30 tablets)

Please note: The costs of Olaparib are subject to change. Check the latest price with the manufacturer selected. 

FDA Approval of Olaparib for Different Cancers

1. Olaparib for Breast Cancer
   • Approved for use in metastatic breast cancer with BRCA mutations.
   • FDA approval for breast cancer in both early and metastatic stages.
2. Olaparib for Ovarian Cancer
   • FDA approval for ovarian cancer treatment, particularly in patients with BRCA mutations or homologous recombination deficiency (HRD).
3. Olaparib for Prostate Cancer
   • FDA approval for prostate cancer in patients with BRCA mutations or similar genetic abnormalities.
4. Olaparib in Pancreatic Cancer
   • Used for pancreatic cancer treatment, particularly for patients with BRCA mutations.
5. Olaparib for Lung Cancer
   • Clinical research is ongoing to evaluate its potential in lung cancer.
6. Olaparib in Gastric Cancer
   • Studies exploring efficacy in gastric cancer.

Advantages of Olaparib

Affordability: One of the primary benefits of Indian generic Olaparib is its affordability. By offering a cost-effective alternative to the brand-name version, it ensures that more patients have access to this life-saving medication, minimizing the financial burden on individuals and healthcare systems.

Quality Assurance: Despite being a generic formulation, Indian generic Olaparib upholds the same high standards of quality and efficacy as its branded counterpart. Manufactured by reputable, WHO, FDA, and GMP-certified companies in India, these medications are produced under strict regulatory guidelines. This guarantees that the quality and effectiveness of the generic Olaparib are not compromised, ensuring patient safety and therapeutic success.

How Olaparib Works?

Olaparib is a targeted cancer treatment that stops cancer cells from fixing their damaged DNA.

Here’s how it works:

• PARP Protein Blocked: Normally, cancer cells use a repair tool called the PARP protein to fix this damage and keep growing.
• Olaparib Blocks PARP: Olaparib stops PARP from working, so cancer cells can’t repair themselves.
• Cancer Cell Death: Without repairs, the cancer cells get too damaged and die, while healthy cells remain mostly unaffected.

Side Effects of Olaparib

• Common Side Effects of Olaparib: Nausea, fatigue, anemia, decreased appetite, and abdominal pain.
• Serious Side Effects: Risk of myelodysplastic syndrome (MDS) and acute leukemia in some patients.

Olaparib and combination therapies with other drugs.

• Olaparib and Abiraterone: Used in prostate cancer treatments.
• Olaparib and Enzalutamide: Explored for combination in prostate cancer therapy.
• Olaparib and Bevacizumab: Combination with Bevacizumab (an anti-angiogenesis drug) in clinical trials for various cancers.
• Olaparib and Talazoparib: Both are PARP inhibitors, and research is ongoing to compare their efficacy and safety.

Comparison with other Drugs

• Olaparib vs Niraparib: Both are PARP inhibitors, but they may differ in efficacy, side effects, and indications.
• Olaparib vs Talazoparib: Another PARP inhibitor; comparison of efficacy in various cancers.
• Olaparib vs Rucaparib: Comparison between different PARP inhibitors in terms of treatment outcomes.
• Olaparib vs Chemotherapy: In some cancers, Olaparib may offer a less toxic alternative to traditional chemotherapy.
• Olaparib and Abemaciclib: Combination therapy research in certain cancers.

In Conclusion

• Olaparib plays a critical role in treating cancers with specific genetic mutations, such as BRCA mutations in breast, ovarian, prostate, and pancreatic cancers.
• Ongoing research continues to explore its role in combination therapies and other cancer types.
• As research progresses, Olaparib may be approved for more indications, and generic versions may make it more affordable in the future.

How to take Olaparib?

Take tablets twice daily, as doses are prescribed by your doctor.

Note: Please consult with your doctor about the dosage

FAQs

Is Olaparib available in India?
Yes, it’s available in generic versions.

What is the cost of Olaparib Zydus?
Olaparib Zydus costs INR 45,000 (approx.) for a monthly supply.

Who is the manufacturer of Olaparib in India?
Zydus, Glenmark, Dr Reddy’s, Cipla, Intas, and Natco Pharma are among the Olaparib manufacturers in India

Is Olaparib a chemotherapy drug?
No, it is a targeted therapy.

Is Olaparib immunotherapy?
No, Olaparib is not an immunotherapy. It is a targeted therapy.

How long does Olaparib work?
Olaparib’s effectiveness varies; usually several months to years

What happens when Olaparib stops working?
If it stops working, cancer may progress, & alternative treatments are needed.

 

References –

https://medlineplus.gov/druginfo/meds/a614060.html

https://www.drugs.com/olaparib.html

https://my.clevelandclinic.org/health/drugs/20482-olaparib-tablets

https://www.businesswireindia.com/zydus-launches-ibyra-generic-version-olaparib-brings-both-access-affordability-cancer-patients-india-89203.html

https://en.wikipedia.org/wiki/Olaparib

https://www.telegraphindia.com/health/cancer-drug-at-24-times-lower-cost-patent-ends-rs-72-lakh-medicine-for-rs-3-lakh/cid/2006709

 

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